Fri Oct 21 2022

23 articles - From Friday Oct 14 2022 to Friday Oct 21 2022

parm_toc.knit

Guidelines

Guidelines, position statements, white papers, technical reviews, consensus statements, etc…

Nephrol Dial Transplant

Clinical implications and guidelines for CKD in type 2 diabetes.

Current guidelines continue to recommend screening for CKD, blood pressure control using RAS inhibition as first line therapy, and glucose control. SGLT2 inhibition and finerenone are recent additions to current guidelines to improve CKD outcomes in T2D, based on robust clinical trial data.

Pubmed   Journal   ReadQx 

Overcoming barriers to implementing new guideline-directed therapies for chronic kidney disease.

These barriers to optimal cardiorenal outcomes can be ameliorated by a multifaceted approach, using the Chronic Care Model framework, to include patient and provider education, patient self-management programs, shared decision making, electronic clinical decision support tools, quality improvement initiatives, clear practice guidelines, multidisciplinary and collaborative care, provider accountability, and robust health information technology. It is incumbent on the global kidney community to take on a multidimensional perspective of CKD care by addressing patient, community, provider, healthcare system, and policy-level barriers.

Pubmed   Journal   ReadQx 


Meta-analysis

meta-analyses and systematic reviews


Original articles

RCT, clinical trials, retrospective studies, etc…

Am J Kidney Dis

Associations Between Ambient Extreme Heat Exposure and Emergency Department Visits Related to Kidney Disease.

Extreme heat exposure was significantly associated with a dose-dependent increased risk of ED visits for kidney disease.

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Characteristics of and Outcomes After Dialysis-Treated Acute Kidney Injury 2009-2018: A Taiwanese Multicenter Study.

We observed reductions in mortality among ICU patients with dialysis-requiring AKI between 2009 and 2018, even after adjusting for dialysis indication and severity of illness at dialysis initiation. However, dialysis dependence among survivors has increased over time, mainly in patients with pre-existing CKD.

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Clonal Hematopoiesis of Indeterminate Potential and Kidney Function Decline in the General Population.

We report an association between CHIP and kidney function decline in three general population cohorts without known kidney disease. Further studies are needed to investigate this novel condition and its potential impact among individuals with overt kidney disease.

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Focal Segmental Glomerulosclerosis Complicating Therapy With Inotersen, an Antisense Oligonucleotide Inhibitor: A Case Report.

This case adds to spectrum of renal disease associated with inotersen and indicates that discontinuation of the drug alone may result in resolution of renal complications without additional immunosuppression. Monitoring of renal function is essential in patients with ATTRv receiving inotersen, particularly if there is evidence of existing renal amyloid.

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Short-term Blood Pressure Variability and Incident CKD in Patients With Hypertension: Findings From the Cardiovascular and Metabolic Disease Etiology Research Center-High Risk (CMERC-HI) Study.

Short-term BPV is associated with the development of a kidney disease composite outcome in hypertensive patients.

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Use of Histologic Parameters to Predict Glomerular Disease Progression: Findings From the China Kidney Biopsy Cohort Study.

Adding histologic chronicity scores to the KFRE model improved the prediction of kidney disease progression at the time of kidney biopsy in patients with glomerular diseases.

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J Am Soc Nephrol

A New DDX58 Pathogenic Variant Causes Lupus Nephritis Due to RIG-I Hyperactivation and its Clinical Implication.

R109C variant that can cause LN, connects IFNopathy and LN, suggesting targeted therapy based on pathogenicity.

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Anatomical Evidence for Parasympathetic Innervation of the Renal Vasculature and Pelvis.

Cholinergic nerves supply renal vasculature and renal pelvis, and a vagal brain-kidney axis is involved in renal innervation.

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Designing Interventions Addressing Structural Racism to Reduce Kidney Health Disparities: A Report from an NIDDK Workshop.

Participants identified six domains as key targets for interventions and future research: 1) apply an anti-racism lens, 2) promote structural interventions, 3) target multiple levels, 4) promote effective community and stakeholder engagement, 5) improve data collection, and 6) advance health equity through new healthcare models. There exists an urgent need for research to develop, implement and evaluate interventions that address the unjust systems, policies, and laws that generate and perpetuate inequities in kidney health.

Pubmed   Journal   ReadQx 

Designing Interventions Addressing Structural Racism to Reduce Kidney Health Disparities: A Report from an NIDDK Workshop.

Participants identified six domains as key targets for interventions and future research: 1) apply an anti-racism lens, 2) promote structural interventions, 3) target multiple levels, 4) promote effective community and stakeholder engagement, 5) improve data collection, and 6) advance health equity through new healthcare models. There exists an urgent need for research to develop, implement and evaluate interventions that address the unjust systems, policies, and laws that generate and perpetuate inequities in kidney health.

Pubmed   Journal   ReadQx 

Nephrol Dial Transplant

Association of chronic kidney disease with total and site-specific cancer incidence in participants of the Japan Public Health Center-based Prospective Study.

In this large prospective study, a low eGFR was not significantly associated with an increased risk of total cancer incidence in patients with CKD, which may be partly due to an underpowered sample size. This finding may be due to the many shared risk factors between CKD and cancer.

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Self-reported health change in haemodialysis recipients modulates the effect of frailty upon mortality and hospital admissions: outcomes from a large prospective UK cohort.

We confirm the high burden of hospitalisation and mortality associated with haemodialysis patients regardless of frailty tool utilised and introduce the discriminatory ability of self-reported health to identify the most at-risk frail individuals.

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Steroidal or non-steroidal MRAs: should we still enable RAASi use through K binders?

Sodium-glucose cotransporter-2 inhibitors also decrease hyperkalemia risk in patients on MRAs and decrease cardiovascular events and kidney disease progression. These may be better first-line interventions to obviate the need for potassium binders and offer additional benefits.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Kidney Int

Blood pressure effects of sodium transport along the distal nephron.

However, what also has become clear is that aldosterone itself only stimulates a portion of the mineralocorticoid receptors along this segment, with the others being activated by glucocorticoid hormones instead. These recent insights provide an increasingly clear picture of how this short nephron segment contributes to blood pressure homeostasis and have important implications for hypertension prevention and treatment.

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Nat Rev Nephrol

Cisplatin nephrotoxicity: new insights and therapeutic implications.

However, the effects of renoprotective strategies on the efficacy of cisplatin chemotherapy needs to be thoroughly evaluated. Further research using tumour-bearing animals, multi-omics and genome-wide association studies will enable a comprehensive understanding of the complex cellular and molecular mechanisms of cisplatin nephrotoxicity and potentially lead to the identification of specific targets to protect the kidney without compromising the chemotherapeutic efficacy of cisplatin.

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Therapeutic advances in COVID-19.

Importantly, patients with acute and chronic kidney disease were under-represented in many of the COVID-19 clinical trials, and outcomes in this population might differ from those reported in the general population. Here, we examine the clinical evidence for these therapies through a kidney medicine lens.

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Trained immunity - basic concepts and contributions to immunopathology.

In organ transplantation, trained immunity has been associated with acute rejection and suppression of trained immunity prolonged allograft survival. This novel concept provides a better understanding of the involvement of the innate immune response in different pathological conditions, and provides a new framework for the development of therapies and treatment strategies that target epigenetic and metabolic pathways of the innate immune system.

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Clin J Am Soc Nephrol

Community Houses to Increase Access to Home Dialysis.

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Nephrol Dial Transplant

Bioimpedance in CKD: an untapped resource?

Pubmed   Journal   ReadQx 


Letters&Replies

Letters to the editors and authors’ replies

Am J Kidney Dis

Prognostic Value of Diffuse Crescentic Lesions in Fibrillary Glomerulonephritis.

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Short-term Healthy Lifestyle Intervention and Long-term Behavior Change After Kidney Transplantation: Findings From the CAVIAR Study.

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